The largest employers in St. Petersburg, including Downtown St. Pete, are mostly the providers of health care jobs. Baycare Health Systems employs 1,308 people, making it the largest employer in the region. University Community Hospital is a close second on the list of the largest employers in St Petersburg, with 1,207 employees. HCA Shared Services, Physician's Services company, employs around 800 people in the St Petersburg area. Bon Secours Catholic Health Care Ministry is headquartered in St Petersburg and employs 21,000 people in seven states.

Jobs in St. Petersburg are not as numerous as in larger metropolitan areas, because the St. Petersburg area is not as large as other cities. Therefore, the opportunities will not be as numerous.

Pizza Hut is another major provider of jobs in the St. Petersburg area of Florida. Pizza Hut employs 438 people, with their restaurants, pizza delivery services, and general company offices. Pizza Hut is a nationally recognized chain of restaurants, so their presence in St Petersburg is a good thing for the St Petersburg economy.

Advance Auto Parts is another national chain that is present in the St Petersburg area. Advance Auto Parts, a well-known auto parts distributor, is one of the best places to work in St Petersburg, employing 337 people.

Jabil Circuit, the electronic problem solutions company, was founded in 1966 in Detroit, Michigan. Today, their headquarters are in St Petersburg. They employ over 100,000 people, at fifty-nine different offices located in twenty-two countries in North America, South America, Europe, and Asia.

Florida Power and Light, a public utility company that provides power throughout the state are headquartered in St Petersburg. Florida Power and Light employ 10,992 people throughout the state, but the number of employees working out of their St Petersburg headquarters only numbers about 100.

St. Petersburg is not a major American city, yet there are plenty of job opportunities available throughout the area, including Downtown St. Pete. Many of these employers are listed as best places to work in St Petersburg.